Yohei Shirakami Selected Research

Branched-Chain Amino Acids

1/2016	Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents.
7/2014	Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities.
1/2014	Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids.
12/2012	Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice.
12/2012	Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.
2/2010	Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
5/2009	Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

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Yohei Shirakami Research Topics

Disease

38	Carcinogenesis 01/2023 - 05/2008
35	Neoplasms (Cancer) 02/2024 - 05/2008
25	Inflammation (Inflammations) 12/2021 - 05/2008
22	Hepatocellular Carcinoma (Hepatoma) 02/2024 - 04/2008
17	Obesity 03/2020 - 09/2008
12	Body Weight (Weight, Body) 02/2017 - 05/2008
10	Colorectal Neoplasms (Colorectal Cancer) 12/2021 - 09/2008
8	Liver Neoplasms (Liver Cancer) 01/2023 - 04/2008
8	Insulin Resistance 01/2016 - 05/2009
5	Alcoholic Fatty Liver 05/2023 - 12/2015
5	Colitis 12/2021 - 05/2008
5	Colonic Neoplasms (Colon Cancer) 12/2020 - 05/2009
5	Non-alcoholic Fatty Liver Disease 08/2017 - 01/2013
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2014 - 02/2010
4	Fibrosis (Cirrhosis) 02/2024 - 01/2013
4	Fatty Liver 05/2023 - 01/2011
4	Liver Diseases (Liver Disease) 09/2017 - 01/2012
4	Aberrant Crypt Foci 12/2014 - 09/2008
3	Adenoma (Adenomas) 01/2022 - 03/2016
3	Adenocarcinoma 12/2021 - 08/2014
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2017 - 07/2013
3	Hyperinsulinism (Hyperinsulinemia) 03/2016 - 05/2009
3	Diabetes Mellitus 03/2016 - 09/2008
3	Malnutrition (Nutritional Deficiencies) 07/2014 - 12/2012
2	Tuberculosis (Tuberculoses) 04/2024 - 11/2018
2	Weight Loss (Weight Reduction) 12/2021 - 03/2016
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2021 - 09/2018
2	Hypertension (High Blood Pressure) 11/2021 - 07/2013
2	Infections 09/2020 - 09/2019
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 09/2020 - 09/2015
2	Hyperlipidemias (Hyperlipidemia) 07/2014 - 07/2010
2	Dyslipidemias (Dyslipidemia) 01/2014 - 07/2013
1	Cholangiocarcinoma 09/2023
1	Muscular Atrophy (Muscle Atrophy) 05/2023

Drug/Important Bio-Agent (IBA)

14	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 02/2024 - 01/2009
14	TeaIBA 09/2018 - 05/2008
12	AzoxymethaneIBA 09/2023 - 05/2008
11	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2022 - 02/2010
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2010
8	Drinking WaterIBA 03/2020 - 05/2008
8	RetinoidsIBA 09/2017 - 01/2009
7	Branched-Chain Amino AcidsIBA 01/2016 - 05/2009
6	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2022 - 01/2011
6	Insulin-Like PeptidesIBA 03/2020 - 04/2008
6	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2016 - 05/2008
5	sodium sulfate (sodium bisulfate)FDA LinkGeneric 12/2021 - 05/2008
5	Dextrans (Dextran)FDA Link 12/2021 - 05/2008
5	AdipokinesIBA 03/2016 - 07/2010
5	Messenger RNA (mRNA)IBA 03/2016 - 01/2011
5	Phosphotransferases (Kinase)IBA 03/2015 - 06/2008
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 05/2021
4	Insulin (Novolin)FDA Link 03/2020 - 04/2008
4	tyrosine receptor (receptor, tyrosine)IBA 03/2015 - 06/2008
3	Vitamin A (Retinol)FDA LinkGeneric 02/2024 - 01/2009
3	CarcinogensIBA 09/2023 - 01/2013
3	CateninsIBA 01/2022 - 01/2014
3	EnzymesIBA 01/2022 - 02/2012
3	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2021 - 01/2013
3	AntioxidantsIBA 03/2016 - 01/2013
3	Mitogen-Activated Protein KinasesIBA 01/2014 - 05/2008
3	IGF Type 1 Receptor (IGF 1 Receptor)IBA 03/2011 - 04/2008
3	beta CateninIBA 07/2010 - 09/2008
2	Tryptophan (L-Tryptophan)FDA Link 05/2023 - 09/2015
2	UbiquitinIBA 05/2023 - 01/2022
2	MicroRNAs (MicroRNA)IBA 04/2022 - 05/2021
2	Hemoglobins (Hemoglobin)IBA 11/2021 - 11/2018
2	6- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA 12/2019 - 08/2017
2	LigandsIBA 05/2019 - 10/2012
2	Pentoxifylline (Trental)FDA LinkGeneric 09/2018 - 05/2016
2	lecithin-retinol acyltransferaseIBA 09/2017 - 02/2012
2	PhytochemicalsIBA 04/2017 - 07/2014
2	Cimetidine (Biomet)FDA LinkGeneric 01/2017 - 02/2016
2	clobenpropitIBA 01/2017 - 02/2016
2	Glucose (Dextrose)FDA LinkGeneric 03/2016 - 02/2010
2	astaxanthine (astaxanthin)IBA 03/2016 - 12/2014
2	Sodium Glutamate (Accent)IBA 03/2016 - 12/2015
2	Catechin (Z 7300)IBA 01/2016 - 06/2008
2	CytokinesIBA 08/2014 - 07/2014
2	pitavastatin (itavastatin)FDA Link 07/2014 - 07/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2010 - 10/2009
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 05/2010 - 10/2009
2	Caseins (Casein)FDA Link 02/2010 - 05/2009
2	Retinoid X Receptor alphaIBA 11/2009 - 05/2008
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2009 - 04/2008
2	Alitretinoin FDA Link 01/2009 - 05/2008
1	N-Myc Proto-Oncogene ProteinIBA 02/2024
1	Ligases (Synthetase)IBA 05/2023
1	SpermidineIBA 05/2023
1	Alanine Transaminase (SGPT)IBA 05/2023
1	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2023
1	GlycosyltransferasesIBA 01/2023
1	Prednisone (Sone)FDA LinkGeneric 01/2022
1	tocilizumab (atlizumab)FDA Link 01/2022

Therapy/Procedure

23	Chemoprevention 12/2021 - 04/2008
6	Subcutaneous Injections 09/2017 - 07/2010
4	Therapeutics 01/2023 - 01/2009
4	Intraperitoneal Injections 07/2014 - 05/2008
2	Drug Therapy (Chemotherapy) 12/2020 - 01/2009
2	Injections 05/2009 - 09/2008
1	Colonoscopes 04/2024